Clear cell chondrosarcoma

Clear cell chondrosarcoma

  • Sheets of polygonal cells

  • Pale eosinophilic-clear cytoplasm

  • Round-ovoid nuclei with mild pleomorphism; inconspicuous mitotic activity

  • Focal hyaline cartilage; bands of osteoid with focal mineralization; prominent osteoclast-type giant cells

Clear cell chondrosarcoma

  • Sheets of polygonal cells

  • Pale amphophilic cytoplasm

  • Round-ovoid nuclei with vesicular chromatin and mild pleomorphism; inconspicuous mitotic activity

  • Focal hyaline cartilage; bands of osteoid with focal mineralization; prominent osteoclast-type giant cells

Clear cell chondrosarcoma

  • Sheets of polygonal cells

  • Pale eosinophilic-clear cytoplasm

  • Round-ovoid nuclei with vesicular chromatin and mild pleomorphism; inconspicuous mitotic activity

  • Focal hyaline cartilage, with osteoid; prominent osteoclast-type giant cells

Clear cell chondrosarcoma

  • Sheets of polygonal cells

  • Pale eosinophilic-clear cytoplasm

  • Round-ovoid nuclei with vesicular chromatin and mild pleomorphism; inconspicuous mitotic activity

  • Areas of hyaline cartilage; bands-sheets of osteoid with mineralization; prominent osteoclast-type giant cells

  • IHC: SATB2

Clear cell chondrosarcoma

  • Sheets of polygonal cells

  • Clear-eosinophilic cytoplasm

  • Hyperchromatic round-ovoid nuclei with mild pleomorphism; inconspicuous mitotic activity

  • Focal hyaline cartilage; bone trabeculae with variable mineralization; occasional osteoclast-type giant cells

Clear cell chondrosarcoma

  • Lobulated; sheets of polygonal cells

  • Clear-eosinophilic cytoplasm

  • Round-ovoid nuclei with mild pleomorphism; inconspicuous mitotic activity

  • Sheets of hyaline cartilage; areas of osteoid with variable mineralization; rare osteoclast-type giant cells