Pathology: Soft Tissue Tumours
Adipocytic tumours
Fibroblastic / Myofibroblastic tumours
Benign
Proliferative fasciitis and proliferative myositis
Myositis ossificans and fibro-osseous pseudotumour of digits
Calcifying aponeurotic fibroma
EWSR1::SMAD3 - positive fibroblastic tumour
Intermediate (locally aggressive)
Intermediate (rarely metastasizing)
Dermatofibrosarcoma protuberans
Inflammatory myofibroblastic tumour
Superficial CD34-positive fibroblastic tumour
Myxoinflammatory fibroblastic sarcoma
Malignant
Sclerosing epithelioid fibrosarcoma
Pending consideration as a distinct entity
Plexiform myofibroblastoma (emerging)
PRRX1-rearranged fibroblastic tumour (emerging)
So-called fibrohistocytic tumours
Benign
Tenosynovial giant cell tumour
Intermediate (rarely metastasizing)
Plexiform fibrohistiocytic tumour
Giant cell tumour of soft parts
Malignant
Vascular tumours
Benign
Intermediate (locally aggressive)
Kaposiform haemangioendothelioma
Intermediate (rarely metastasizing)
Retiform haemangioendothelioma
Papillary intralymphatic angioendothelioma
Composite haemangioendothelioma
Pseudomyogenic haemangioendothelioma
Malignant
Pericytic tumours
Smooth muscle tumours
Benign
Intermediate
EBV-associated smooth muscle tumour
Malignant
Leiomyosarcoma, not otherwise specified
Pending reclassification
Skeletal muscle tumours
Benign
Malignant
Spindle cell / Sclerosing rhabdomyosarcoma
Pending consideration as a distinct entity
Histiocyte-rich rhabdomyoblastic tumour
Gastrointestinal stromal tumours
Chondro-osseous tumours
Peripheral nerve sheath tumours
Tumours of uncertain origin / differentiation
Benign
Pleomorphic hyalinizing angiectatic tumour
Phosphaturic mesenchymal tumour
Intermediate (locally aggressive)
Haemosiderotic fibrolipomatous tumour
Perivascular epithelioid tumour (PEComa)
Intermediate (rarely metastasizing)
Angiomatoid fibrous histiocytoma
Malignant
NTRK-rearranged spindle cell neoplasms (emerging)
Clear cell sarcoma of soft tissue
Extraskeletal myxoid chondrosarcoma
Desmoplastic small round cell tumour
Undifferentiated sarcoma (spindle, epithelioid, round, pleomorphic)
Round cell sarcoma with EWSR1—non-ETS fusions
Pending consideration as a distinct entity
Calcified chondroid mesenchymal neoplasm (emerging)
GLI1-altered soft tissue neoplasm (emerging)
Keratin-positive giant cell-rich soft tissue tumour (emerging)
Myoepithelioma-like hyalinizing epithelioid tumour (emerging)
NUTM1-rearranged sarcoma (emerging)