Pathology: dedifferentiated chordoma

Dedifferentiated chordoma

• Spindle-epithelioid cells with storiform-fascicular pattern

• Eosinophilic cytoplasm with rare vacuoles

• Round-ovoid nuclei with moderate pleomorphism; conspicuous mitotic activity

Local recurrence ~10 years after resection of chordoma (patient received neoadjuvant radiotherapy, so the possibility of a radiation-associated sarcoma cannot be entirely excluded)