Gastrointestinal pathology

Liver

Leiomyosarcoma

  • IHC: H-caldesmon

Lumenal

Clear cell sarcoma-like tumour of the gastrointestinal tract

  • RNA-seq: EWSR1-CREB1 gene fusion

Liposarcoma, dedifferentiated

  • IHC: MDM2, CDK4

  • FISH: MDM2 gene amplification


Epithelial-stromal polyp, sessile serrated polyp (perineurioma)

  • DNA-seq: BRAF; c.1799T >A (p.Val600Glu)

  • PMID: 15958849, 33313671

Gastroblastoma

  • RNA-seq: MALAT1-GLI1 gene fusion

  • PMID: 28731043

Kaposi sarcoma

  • IHC: ERG, HHV8

Leiomyoma

  • IHC: H-caldesmon, CD34, CD117, DOG1

  • DNA-seq: negative

NB: colonization and hyperplasia [of leiomyoma] by non-neoplastic interstitial cells of Cajal. PMID: 24145645

Leiomyosarcoma

  • IHC: smooth muscle actin, H-caldesmon

Leiomyosarcoma

  • IHC: H-caldesmon

Leiomyosarcoma

  • IHC: H-caldesmon

Lipoma

  • FISH: MDM2 non-amplified

Plexiform fibromyxoma

  • IHC: CD56, smooth muscle actin

  • RNA-seq: MALAT1-GLI1 gene fusion

  • PMID: 19675452, 27101025

Schwannoma

  • IHC: S100, SOX10

Sclerosing epithelioid fibrosarcoma (primary)

  • IHC: MUC4

  • RNA-seq: FUS-CREB3L2 gene fusion

Synovial sarcoma (primary)

  • IHC: keratin (AE1/AE3)

  • RNA-seq: SS18-SSX1 gene fusion