Pathology: PRRX1-rearranged fibroblastic tumour

PRRX1-rearranged fibroblastic tumour

  • Variable cellularity; spindle-ovoid cells in vague fascicles and clusters

  • Eosinophilic cytoplasm

  • Monomorphic ovoid nuclei; inconspicuous mitotic activity

  • Abundant stroma comprised of thin collagen filaments; thin-walled ectatic-curvilinear vasculature

  • IHC: S100

  • RNA-seq: PRRX1-NCOA1 gene fusion

  • PMID: 31008539

PRRX1-rearranged fibroblastic tumour

  • Circumscribed; cellular; spindle-ovoid cells in vague fascicles

  • Eosinophilic cytoplasm

  • Monomorphic ovoid nuclei; inconspicuous mitotic activity

  • Myxoid stroma with prominent thin collagen filaments; thin-walled ectatic-curvilinear vasculature

  • RNA-seq: PRRX1-NCOA1 gene fusion

  • PMID: 31008539