Loose fascicles of spindle-stellate cells
Pale and eosinophilic cytoplasm
Monomorphic ovoid nuclei; inconspicuous mitotic activity
Collagenous-myxoid stroma
IHC: MUC4
RNA-seq: FUS::CREB3L1 gene fusion
Loose fascicles of spindle-stellate cells
Pale and eosinophilic cytoplasm
Monomorphic ovoid nuclei; inconspicuous mitotic activity
Giant collagen rosettes
IHC: MUC4
RNA-seq: FUS::CREB3L2 gene fusion
Variably cellularity; spindle-stellate cells with vague fascicular pattern
Scant pale and eosinophilic cytoplasm
Monomorphic ovoid nuclei; inconspicuous mitotic activity
Myxoid-collagenous stroma with delicate curvilinear vasculature
IHC: MUC4
RNA-seq: FUS::CREB3L2 gene fusion
Hypocellular; spindle cells with loose fascicular-storiform pattern
Pale eosinophilic cytoplasm with long tapering processes
Monomorphic ovoid nuclei; inconspicuous mitotic activity
Prominent myxoid stroma; condensation of tumour around delicate curvilinear vessels
IHC: MUC4
RNA-seq: FUS::CREB3L2 gene fusion
Hypocellular; spindle cells with loose fascicular-storiform pattern
Pale eosinophilic cytoplasm with long tapering processes
Monomorphic ovoid nuclei; inconspicuous mitotic activity
Prominent fibromyxoid stroma; condensation of tumour around delicate curvilinear vessels
IHC: MUC4
RNA-seq: FUS::CREB3L2 gene fusion
Hypocellular; spindle cells with loose fascicular-storiform pattern
Pale eosinophilic cytoplasm with long tapering processes
Monomorphic ovoid nuclei; inconspicuous mitotic activity
Prominent fibrous stroma; occasional ectatic thin-walled vessels
RNA-seq: FUS::CREB3L2 gene fusion
Hypocellular; spindle-stellate cells with loose fascicular-storiform pattern
Pale eosinophilic cytoplasm with delicate tapering processes
Monomorphic ovoid nuclei; inconspicuous mitotic activity
Prominent myxoid stroma; occasional short thin-walled vessels
RNA-seq: FUS::CREB3L2 gene fusion
Hypocellular; spindle-stellate cells with loose fascicular-storiform pattern
Pale eosinophilic cytoplasm with delicate tapering processes
Monomorphic ovoid nuclei; inconspicuous mitotic activity
Prominent myxoid stroma; occasional short thin-walled vessels
IHC: MUC4
Cellular; spindle-epithelioid cells with vague fascicular pattern
Pale eosinophilic cytoplasm
Monomorphic ovoid nuclei; occasional mitotic activity
Areas of fibrous stroma; delicate curvilinear vasculature
IHC: MUC4
RNA-seq: FUS::CREB3L1 gene fusion
Cellular; spindle-epithelioid cells with vague fascicular pattern
Pale eosinophilic cytoplasm
Monomorphic ovoid nuclei; inconspicuous mitotic activity
Areas of fibrous stroma; delicate curvilinear vasculature
IHC: MUC4
RNA-seq: FUS::CREB3L2 gene fusion
Lobulated; variable cellularity; spindle-epithelioid cells with vague fascicular pattern
Pale eosinophilic cytoplasm
Monomorphic ovoid nuclei; occasional mitotic activity
Prominent hyalinized stroma forming so-called "pseudorosettes"; delicate curvilinear vasculature
IHC: MUC4
FISH: FUS-rearrangement
PMID: 9414192