Pathology: pseudomyogenic haemangioendothelioma

Pseudomyogenic haemangioendothelioma

  • Spindle cell fascicles

  • Pale amphophilic cytoplasm

  • Monomorphic ovoid nuclei with vesicular chromatin and small nucleoli; inconspicuous mitotic activity

  • Mild lymphocytic infiltrate

  • IHC: ERG, keratin (AE1/AE3)

  • RNA-seq: ACTB::FOSB gene fusion

  • PMID: 30256258


Pseudomyogenic haemangioendothelioma

  • Spindle cell fascicles

  • Pale amphophilic cytoplasm

  • Monomorphic ovoid nuclei with vesicular chromatin and small nucleoli; inconspicuous mitotic activity

  • Mild lymphocytic infiltrate

  • RNA-seq: SERPINE1::FOSB gene fusion

  • PMID: 24374978

Pseudomyogenic haemangioendothelioma

  • Multifocal; fascicles of spindle-stellate cells

  • Eosinophilic cytoplasm

  • Hyperchromatic ovoid nuclei with mild pleomorphism; inconspicuous mitotic activity

  • Loose fibrous stroma

  • IHC: CD31, ERG, keratin (AE1/AE3)

  • RNA-seq: MED15::FOSB gene fusion*

* To date unreported in literature

Pseudomyogenic haemangioendothelioma

  • Multifocal; fascicles of spindle-stellate cells

  • Pale eosinophilic cytoplasm

  • Elongated ovoid nuclei with vesicular chromatin and small nucleoli; inconspicuous mitotic activity

  • Intervening myxoid stroma

  • RNA-seq: SERPINE1::FOSB gene fusion

  • PMID: 24374978