Gynecologic pathology

Cervix

Superficial cervicovaginal myofibroblastoma

  • IHC: smooth muscle actin

  • PMID: 15693885

Uterus

Adenosarcoma

  • IHC: MDM2, CDK4

  • FISH: MDM2 amplified

Adenosarcoma

  • IHC: MDM2, CDK4

  • FISH: MDM2 amplified

Adenosarcoma, sarcomatous overgrowth

  • IHC: CD10, Cyclin D1, MDM2, CDK4

  • FISH: MDM2 amplified

Blue naevus

  • Special stain: Schmorl's

  • IHC: S100, SOX10, HMB45

  • DNA-seq: CKIT exon 13 c.1975G>T (p.Ala659Ser)*

* To date unreported in the literature

Embryonal rhabdomyosarcoma

  • IHC: desmin, myogenin

Endometrial stromal sarcoma, low-grade

  • RNA-seq: JAZF1::SUZ12 gene fusion

Endometrial stromal sarcoma, low-grade

  • RNA-seq: JAZF1::SUZ12 gene fusion

Endometrial stromal sarcoma, low-grade

  • IHC: CD10

  • RNA-seq: JAZF1::SUZ12 gene fusion

Endometrial stromal sarcoma, low-grade

  • RNA-seq: JAZF1::SUZ12 gene fusion

Endometrial stromal sarcoma, low-grade

  • RNA-seq: EPC1::SUZ12 gene fusion

Endometrial stromal sarcoma, low-grade

  • RNA-seq: JAZF1::PHF1 gene fusion

Endometrial stromal sarcoma, low-grade

  • RNA-seq: HIPK1::MEAF6 gene fusion*

* To date unreported in the literature

Endometrial stromal sarcoma, high-grade

  • RNA-seq: YWHAE::NUTM2B gene fusion

Endometrial stromal sarcoma, high-grade

  • IHC: cyclinD1, estrogen receptor

  • RNA-seq: YWHAE::NUTM2B gene fusion

Endometrial stromal sarcoma, high-grade

  • RNA-seq: EP300::BCOR gene fusion

Endometrial stromal sarcoma, high-grade

  • RNA-seq: EPC1::BCORL1 gene fusion

Endometrial stromal sarcoma, high-grade

  • IHC: CD10, estrogen receptor

  • RNA-seq: JAZF1::BCORL1 gene fusion

Leiomyoma

  • IHC: desmin, smooth muscle actin, H-caldesmon

Leiomyoma, post partum (so-called "red degeneration")

Leiomyosarcoma

  • IHC: H-caldesmon, estrogen receptor

NB: significant differences in diagnostic criteria compared to leiomyosarcoma of soft tissue

Leiomyosarcoma

  • IHC: desmin, smooth muscle actin, H-caldesmon

NB: significant differences in diagnostic criteria compared to leiomyosarcoma of soft tissue

Leiomyosarcoma (metastatic)

  • IHC: H-caldesmon, estrogen receptor

Leiomyosarcoma, dedifferentiated

  • IHC: H-caldesmon

  • PMID: 22175893

Lipoleiomyoma

  • IHC: H-caldesmon

Lipoleiomyosarcoma

  • IHC: H-caldesmon

Lipoleiomyosarcoma

  • IHC: H-caldesmon

Perivascular epithelioid cell tumour (PEComa), malignant

  • IHC: desmin, smooth muscle actin, Melan-A

  • RNA-seq: TSC2 (pQ478)

Uterine Sarcoma with KAT6B/A::KANSL1 fusion

  • RNA-seq: KAT6B::KANSL1 gene fusion

  • IHC: desmin, smooth muscle actin, estrogen receptor, CD10

  • PMID: 35575789

Uterine tumour resembling ovarian sex cord tumour

  • RNA-seq: ESR1::NCOA3 gene fusion

  • PMID: 30273195

Vagina

Fibroepithelial stromal polyp

  • IHC: desmin, myogenin

  • PMID: 23944986

Vulva

Lipoblastoma-like tumour of the vulva

  • IHC: S100

  • PMID: 12047760, 25929353, 29976943

Angiomyofibroblastoma

  • IHC: desmin, estrogen receptor, CD34

Fibroepithelial stromal polyp

Fibroepithelial stromal polyp, cellular

  • IHC: desmin

  • PMID: 10680891

Superficial myofibroblastoma

  • IHC: CD34

  • PMID: 15693885