Pathology: EWSR1::non-ETS rearranged sarcoma

Sheets, cords and chains of epithelioid cells

Pale amphophilic-clear cytoplasm

Round-ovoid nuclei with mild atypia; inconspicuous mitotic activity

Abundant myxo-hyaline stroma

IHC: keratin (AE1/AE3). epithelial membrane antigen

RNA-seq: EWSR1::NFATC2 gene fusion

PMID: 30895378

Fascicles of spindle cells with admixed nests of round cells

Pale amphophilic cytoplasm

Round-ovoid hyperchromatic nuclei with mild pleomorphism and occasional binucleation; mitotic activity

Myxoid stroma with occasional thick collagen bundles 

RNA-seq: EWSR1::TFCP2 gene fusion

PMID: 32556562