Pathology: epithelioid haemangioma

Epithelioid haemangioma

  • Lobulated; loose sheets of epithelioid-spindle cells

  • Eosinophilic cytoplasm with occasional clear vacuoles, some with erythrocytes

  • Ovoid nuclei with prominent nucleoli and mild pleomorphism; inconspicuous mitotic activity

  • IHC: ERG

  • RNA-seq: GATA6-FOXO1 gene fusion

  • PMID: 33318580

Epithelioid haemangioma

  • Multi-lobulated; nests of epithelioid cells

  • Eosinophilic cytoplasm with occasional clear vacuoles, some with amorphous debris

  • Ovoid nuclei with prominent nucleoli and mild pleomorphism; inconspicuous mitotic activity

  • IHC: ERG

  • RNA-seq: GATA6-FOXO1 gene fusion

  • PMID: 33318580

Epithelioid haemangioma

  • Lobulated; epithelioid cells with vasoformative pattern

  • Eosinophilic cytoplasm with occasional clear vacuoles, some with amorphous debris

  • Ovoid nuclei with prominent nucleoli and mild pleomorphism; inconspicuous mitotic activity

  • RNA-seq: negative

Epithelioid haemangioma

  • Lobulated; epithelioid cells with nested and vasoformative patterns

  • Eosinophilic cytoplasm with occasional clear vacuoles, some with erythrocytes

  • Ovoid nuclei with prominent nucleoli and mild pleomorphism; inconspicuous mitotic activity

  • IHC: ERG

  • RNA-seq: negative

Epithelioid haemangioma

  • Epithelioid-spindle cells with nested and vasoformative patterns

  • Eosinophilic cytoplasm with occasional clear vacuoles, some with amorphous debris

  • Ovoid nuclei with prominent nucleoli, vesicular chromatin and mild pleomorphism; occasional mitotic activity

  • IHC: ERG

  • RNA-seq: negative

Epithelioid haemangioma

  • Epithelioid-spindle cells with nested and vasoformative patterns

  • Eosinophilic cytoplasm with occasional clear vacuoles, some with amorphous debris

  • Ovoid nuclei with prominent nucleoli, vesicular chromatin and mild pleomorphism; inconspicuous mitotic activity

  • IHC: CD31, CD34, ERG

  • RNA-seq: negative