Pathology: GLI1-altered soft tissue tumour

Lobulated; epithelioid cells arranged in nests and cords

Eosinophilic cytoplasm

Round nuclei with visible nucleoli; mitotic activity

Haemorrhagic and myxoid stroma 

IHC: smooth muscle actin, beta-catenin, MDM2, SATB2

RNA-seq: ACTB::GLI1 gene fusion

Lobulated; epithelioid-spindle cells arranged in sheets, nests, and whorls 

Pale eosinophilic cytoplasm; occasional intracytoplasmic eosinophilic globules

Ovoid nuclei with inconspicuous nucleoli; inconspicuous mitotic activity

RNA-seq: MALAT1::GLI1 gene fusion

Lobulated; epithelioid-spindle cells in sheets-nests

Pale eosinophilic-clear cytoplasm

Monomorphic ovoid nuclei with prominent nucleoli; inconspicuous mitotic activity

IHC: S100

RNA-seq: ACTB::GLI1 gene fusion