Pathology: GLI1-altered soft tissue tumour
GLI1-altered soft tissue tumour
Lobulated; epithelioid-spindle cells arranged in sheets and whorls
Eosinophilic cytoplasm
Ovoid nuclei with inconspicuous nucleoli; inconspicuous mitotic activity
IHC: S100, SATB2
RNA-seq: MALAT1::GLI1 gene fusion
GLI1-altered soft tissue tumour
Lobulated; epithelioid cells arranged in nests and cords
Eosinophilic cytoplasm
Round nuclei with visible nucleoli; mitotic activity
Haemorrhagic and myxoid stroma
IHC: smooth muscle actin, beta-catenin, MDM2, SATB2
RNA-seq: ACTB::GLI1 gene fusion
GLI1-altered soft tissue tumour
Lobulated; epithelioid-spindle cells arranged in sheets, nests, and whorls
Pale eosinophilic cytoplasm; occasional intracytoplasmic eosinophilic globules
Ovoid nuclei with inconspicuous nucleoli; inconspicuous mitotic activity
RNA-seq: MALAT1::GLI1 gene fusion
GLI1-altered soft tissue tumour
Lobulated; epithelioid-spindle cells in sheets-nests
Pale eosinophilic-clear cytoplasm
Monomorphic ovoid nuclei with prominent nucleoli; inconspicuous mitotic activity
IHC: S100
RNA-seq: ACTB::GLI1 gene fusion