Pathology: GLI1-altered soft tissue tumour

Lobulated; epithelioid-spindle cells in sheets-nests
Pale eosinophilic-clear cytoplasm
Monomorphic ovoid nuclei with prominent nucleoli; inconspicuous mitotic activity
IHC: S100
RNA-seq: ACTB::GLI1 gene fusion

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Soft Tissue Tumours

Tumours of Uncertain Differentiation