Pathology: angiofibroma of soft tissue

Circumscribed; variable cellularity; spindle cells with patternless arrangement 

Scant pale eosinophilic cytoplasm

Monomorphic ovoid nuclei with small nucleoli; inconspicuous mitotic activity

Myxoid-collagenous stroma; complex ramifying capillary-sized vasculature

RNA-seq: AHRR::NCOA2 gene fusion

Circumscribed; variable cellularity; spindle cells with patternless arrangement 

Scant pale eosinophilic cytoplasm

Monomorphic ovoid nuclei with small nucleoli; inconspicuous mitotic activity

Myxoid-collagenous stroma; complex ramifying capillary-sized vasculature

RNA-seq: AHRR::NCOA2 gene fusion

- Circumscribed; variable cellularity; spindle cells with patternless arrangement 

- Scant pale eosinophilic cytoplasm

- Monomorphic ovoid nuclei with small nucleoli; inconspicuous mitotic activity

- Myxoid-collagenous stroma; complex ramifying capillary-sized vasculature

RNA-seq: AHRR::NCOA2 gene fusion

Circumscribed; variable cellularity; spindle cells with patternless arrangement 

Scant pale eosinophilic cytoplasm

Monomorphic ovoid nuclei with small nucleoli; inconspicuous mitotic activity

Myxoid-collagenous stroma; entrapped adipocytes; complex ramifying capillary-sized vasculature

RNA-seq: AHRR::NCOA3 gene fusion

PMID: 36860189 

Circumscribed; variable cellularity; spindle cells with patternless arrangement

Scant pale eosinophilic cytoplasm 

Monomorphic ovoid nuclei with small nucleoli; inconspicuous mitotic activity

Myxoid-collagenous stroma; complex ramifying capillary-sized vasculature 

RNA-seq: AHRR::NCOA2 gene fusion

PMID: 22301504, 22337624 

Circumscribed; variable cellularity; spindle cells with patternless arrangement

Scant pale eosinophilic cytoplasm 

Monomorphic ovoid nuclei with small nucleoli; inconspicuous mitotic activity

Myxoid-collagenous stroma; complex ramifying capillary-sized vasculature 

RNA-seq: AHRR::NCOA2 gene fusion

PMID: 22301504, 22337624