Pathology: keratin-positive giant cell-rich soft tissue tumour

Keratin-positive giant cell-rich soft tissue tumour

  • Sheets of spindle-polygonal cells a vague storiform pattern

  • Pale cytoplasm and indistinct cell borders

  • Monomorphic ovoid nuclei; inconspicuous mitotic activity

  • Interspersed osteoclast-like multinucleated giant cells, foamy histiocytes. and lymphocytes

  • IHC: CD34

  • RNA-seq: HMGA2::NCOR2 gene fusion

  • PMID: 33742141