Pathology: chondroid lipoma

Chondroid lipoma

  • Lobulated with thin fibrous capsule; sheets of small polygonal cells

  • Eosinophilic and variably vacuolated, cytoplasm

  • Round, scalloped nuclei with mild atypia; inconspicuous mitotic activity

  • Interspersed there are mature adipocytes with abundant clear cytoplasm and small peripheral nuclei

Chondroid lipoma

  • Lobulated neoplasm bound by thin fibrous capsule

  • Sheets of small polygonal cells with eosinophilic, and variably vacuolated, cytoplasm

  • Round, scalloped nuclei with mild atypia; inconspicuous mitotic activity

  • Interspersed there are mature adipocytes with abundant clear cytoplasm and small peripheral nuclei

  • RNA-seq: C11orf95-MKL2 gene fusion

Chondroid lipoma

  • Lobulated neoplasm; sheets of polygonal cells

  • Eosinophilic and variably vacuolated cytoplasm

  • Round, scalloped nuclei with mild atypia; inconspicuous mitotic activity

  • Interspersed bands of hyaline stroma; nests and sheets of mature adipocytes with abundant clear cytoplasm and small peripheral nuclei