Pathology: lipoblastoma


  • Polygonal cells arranged in sheets and lobules; bound by thin fibrous septa

  • Abundant clear cytoplasm; variable vacuolation and size, based on extent of maturation

  • Peripherally located small monomorphic nuclei

  • Spindle-stellate cells present in areas of myxoid stroma

  • Often associated with PLAG1- or HMGA2-rearrangement; many potential partners (PMID: 32692992)