Pathology: intimal sarcoma

Intimal sarcoma

  • Spindle-polygonal cells with patternless distribution

  • Pale aeosinophilic cytoplasm

  • Round-ovoid nuclei with prominent nucleoli and moderate pleomorphism; mitotic activity

  • Necrosis

  • IHC: MDM2, CDK4

  • FISH: MDM2 amplified

Intimal sarcoma

  • Polygonal cells with patternless distribution

  • Pale amphophilic cytoplasm

  • Round-ovoid nuclei with prominent nucleoli and marked pleomorphism; mitotic activity

  • Collagenous stroma; prominent ectatic vessels lined by atypical cuboidal endothelial cells; mild chronic inflammation, and eosinophils; necrosis

  • IHC: MDM2, CDK4

  • FISH: MDM2 amplified

Intimal sarcoma

  • Sheets and fascicles of spindle-epithelioid cells

  • Pale amphophilic cytoplasm

  • Round-ovoid nuclei with irregular membranes, small nucleoli, moderate pleomorphism and occasional multinucleation; mitotic activity

  • Myxoid-collagenous stroma; necrosis

  • IHC: MDM2

  • FISH: MDM2 amplified

Intimal sarcoma

  • Spindle-stellate cells with storiform pattern

  • Pale amphophilic cytoplasm with delicate processes

  • Ovoid nuclei with small nucleoli and mild pleomorphism; inconspicuous mitotic activity

  • Focal collagenous stroma; mild chronic inflammation

  • FISH: MDM2 amplified

Intimal sarcoma

  • Spindle-stellate cells with loose fascicular-storiform pattern

  • Pale eosinophilic cytoplasm with delicate processes

  • Ovoid nuclei with small nucleoli and mild pleomorphism; inconspicuous mitotic activity

  • Loose myxoid-collagenous stroma; mild chronic inflammation; necrosis

  • IHC: MDM2

  • FISH: MDM2 amplified