Pathology: angiosarcoma

Angiosarcoma

  • Multilobulated and infiltrative; spindle-epithelioid cells in vague fascicles

  • Eosinophilic-amphophilic cytoplasm

  • Round-ovoid nuclei with prominent nucleoli and moderate pleomorphism; conspicuous mitotic activity

  • Necrosis; mild lymphocytic infiltrate

  • IHC: ERG

Angiosarcoma, radiation-associated

  • Multilobulated and infiltrative; spindle-epithelioid cells in nests-fascicles

  • Amphophilic cytoplasm with occasional vacuoles and erythrocytes

  • Round-ovoid nuclei with prominent nucleoli and moderate pleomorphism; conspicuous mitotic activity

  • Mild lymphocytic infiltrate

  • IHC: c-MYC

Angiosarcoma, radiation-associated

  • Infiltrative; spindle-epithelioid cells in loose fascicles with fenestration

  • Amphophilic cytoplasm

  • Ovoid hyperchromatic nuclei with moderate-marked pleomorphism; conspicuous mitotic activity

  • Mild chronic inflammation; papillary endothelial hyperplasia

  • IHC: ERG, D2-40