Pathology: angiosarcoma
Angiosarcoma
Multilobulated and infiltrative; spindle-epithelioid cells in vague fascicles
Eosinophilic-amphophilic cytoplasm
Round-ovoid nuclei with prominent nucleoli and moderate pleomorphism; conspicuous mitotic activity
Necrosis; mild lymphocytic infiltrate
IHC: ERG
Angiosarcoma, radiation-associated
Multilobulated and infiltrative; spindle-epithelioid cells in nests-fascicles
Amphophilic cytoplasm with occasional vacuoles and erythrocytes
Round-ovoid nuclei with prominent nucleoli and moderate pleomorphism; conspicuous mitotic activity
Mild lymphocytic infiltrate
IHC: c-MYC
Angiosarcoma, radiation-associated
Infiltrative; spindle-epithelioid cells in loose fascicles with fenestration
Amphophilic cytoplasm
Ovoid hyperchromatic nuclei with moderate-marked pleomorphism; conspicuous mitotic activity
Mild chronic inflammation; papillary endothelial hyperplasia
IHC: ERG, D2-40