Pathology: tumours of uncertain differentiation

Benign

Intramuscular myxoma

Juxta-articular myxoma

Deep (aggressive) angiomyxoma

Pleomorphic hyalinizing angiectatic tumour

Phosphaturic mesenchymal tumour

Intermediate (locally aggressive)

Haemosiderotic fibrolipomatous tumour

Peripheral haemangioblastoma

Perivascular epithelioid tumour (PEComa)

Intermediate (rarely metastasizing)

Atypical fibroxanthoma

Angiomatoid fibrous histiocytoma

Ossifying fibromyxoid tumour

Myoepithelial tumour

Malignant

NTRK-rearranged spindle cell neoplasms (emerging)

Synovial sarcoma

Epithelioid sarcoma

Alveolar soft part sarcoma

Clear cell sarcoma of soft tissue

Extraskeletal myxoid chondrosarcoma

Desmoplastic small round cell tumour

Rhabdoid tumour

Intimal sarcoma

Undifferentiated sarcoma (spindle, epithelioid, round, pleomorphic) 

Ewing sarcoma

Round cell sarcoma with EWSR1—non-ETS fusions

CIC-rearranged sarcoma

BCOR-altered sarcoma

Pending inclusion

Calcified chondroid mesenchymal neoplasm (emerging)

EWSR1::CREM positive mesenchymal tumour (emerging)

GLI1-altered soft tissue neoplasm (emerging)

Keratin-positive giant cell-rich soft tissue tumour (emerging)

KMT2A-rearranged sarcoma (emerging)

Lipoblastoma-like tumour (emerging)

Myoepithelioma-like hyalinizing epithelioid tumour  (emerging)

NR1D1-rearranged mesenchymal neoplasm (emerging)

NUTM1-rearranged sarcoma (emerging)

RREB1::MRTFB positive mesenchymal neoplasm (emerging)