Pathology: myxoid liposarcoma

Loose fascicles and strips of spindle-stellate cells with eosinophilic cytoplasm

Monomorphic ovoid-round nuclei

Pools of extracellular mucin with a so-called "pulmonary oedema" pattern; delicate branching vessels; occasional lipoblasts 

RNA-seq: FUS::DDIT3

Strips and loose fascicles of spindle-stellate cells with eosinophilic cytoplasm

Occasional lipoblasts; typically 1-2 intracytoplasmic vacuoles 

Monomorphic ovoid-round nuclei

Pools of extracellular mucin with a so-called "pulmonary oedema" pattern; delicate branching vessels 

RNA-seq: FUS::DDIT3

Nests and fascicles of round-spindle-stellate cells with eosinophilic cytoplasm

Monomorphic ovoid-round nuclei

Pools of extracellular mucin with a so-called "pulmonary oedema" pattern; delicate branching vessels; occasional lipoblasts 

RNA-seq: FUS::DDIT3

Loose fascicles of spindle-stellate cells with eosinophilic cytoplasm

Occasional lipoblasts; typically 1-2 intracytoplasmic vacuoles 

Monomorphic ovoid-round nuclei

Abundant myxoid stroma; delicate branching vessels with a so-called  "chicken-wire" or "crow's foot" pattern

Pools of extracellular mucin with a so-called 'pulmonary oedema' pattern; delicate branching vasculature; scattered small lipoblasts

RNA-seq: FUS::DDIT3

Loose fascicles of spindle-stellate cells with eosinophilic cytoplasm

Monomorphic ovoid-round nuclei

Myxoid stroma; delicate branching vessels; conspicuous lipoblasts 

RNA-seq: FUS::DDIT3

Sheets of round-spindle cells with variable cytoplasm 

Rare lipoblasts with granular eosinophilic cytoplasm

Interspersed areas of myxoid stroma containing delicate branching vasculature

RNA-Seq: FUS::DDIT3

Sheets of round cells with scant cytoplasm 

Occasional lipoblasts; typically 1-2 intracytoplasmic vacuoles 

Minimal intervening matrix, but areas of myxoid stroma can usually be found  

RNA-Seq: FUS::DDIT3

Anatomizing sheets of round-spindle cells with scant cytoplasm 

Occasional lipoblasts with granular eosinophilic cytoplasm and innumerable vacuoles 

Interspersed areas of myxoid stroma containing delicate branching vasculature

RNA-Seq: EWSR1::DDIT3