Sheets-nests of epithelioid-round cells
Pale eosinophilic cytoplasm with occasional vacuoles
Round nuclei with small nucleoli and mild pleomorphism; mitotic activity
Collagenous-hyalinized stroma
IHC: EMA, S100, WT-1
RNA-seq: CIC::DUX4 gene fusion
Sheets of round-epithelioid cells
Pale amphophilic cytoplasm
Round-ovoid nuclei with coarse chromatin, small nucleoli and mild-moderate pleomorphism; mitotic activity
Necrosis
IHC: WT1, CD99
RNA-seq: CIC::DUX4L2 gene fusion
Sheets-nests of round cells
Pale eosinophilic cytoplasm
Round nuclei with small nucleoli and mild pleomorphism; mitotic activity
Delicate thin-walled vasculature
IHC: CD99
FISH: CIC-rearrangement
Sheets-nests of round cells
Pale eosinophilic cytoplasm
Round nuclei with small nucleoli and mild pleomorphism; mitotic activity
Delicate thin-walled vasculature
IHC: CD99, WT1
FISH: CIC-rearrangement