Genitourinary pathology

Bladder

Angiosarcoma, radiation-associated

  • IHC: CD31, ERG, MYC

History of prostate cancer treated with external beam radiotherapy six years earlier.

Angiosarcoma, radiation-associated

  • IHC: ERG, MYC

History of prostate cancer treated with external beam radiotherapy eight years earlier.

Dedifferentiated liposarcoma

  • IHC: MDM2, CDK4

  • FISH: MDM2 amplified

Epithelioid haemangioendothelioma

  • IHC: ERG

  • RNA-seq: WWTR1::CAMTA1 gene fusion

Inflammatory myofibroblastic tumour

  • RNA-seq: FN1::ALK gene fusion

Leiomyosarcoma, cyclophosphamide-associated

  • IHC: H-caldesmon

Postoperative spindle cell nodule

Recent TURBT for low-grade papillary urothelial carcinoma

  • IHC: smooth muscle actin, keratin (AE1/AE3)

  • RNA-seq: negative

Radiation-associated sarcoma

Kidney

Angiomyolipoma

  • IHC: H-caldesmon, HMB45, Melan-A

Epithelioid haemangioendothelioma, metastatic

  • IHC: ERG

  • RNA-seq: WWTR1::ACTL6A gene fusion

This fusion gene has a predilection for tumours of cardiac origin

Ewing sarcoma

  • IHC: CD99

  • RNA-seq: EWSR1::FLI1 gene fusion

Perinephric myxoid pseudotumour

  • PMID: 30826321

Renomedullary interstitial tumour

  • RNA-seq: negative

  • PMID: 4264334, 27635944

Synovial sarcoma. poorly differentiated

  • RNA-seq: SS18::SSX2 gene fusion

Scrotum

Scrotal calcinosis


Spermatic cord

Leiomyosarcoma

  • IHC: desmin, smooth muscle actin, H-caldesmon

Liposarcoma, dedifferentiated

  • IHC: MDM2, CDK4

  • FISH: MDM2 amplified

Liposarcoma, dedifferentiated

  • FISH: MDM2 amplified

Rhabdomyosarcoma, embryonal

  • IHC: myogenin

  • FISH: MDM2 amplified

Paratesticular fibrous pseudotumour

Rhabdomyosarcoma, embryonal

  • IHC: desmin, myogenin

  • FISH: MDM2 non-amplified

  • RNA-seq: negative

Schwannoma

  • IHC: S100

  • PMID: