Genitourinary pathology
Bladder
Angiosarcoma, radiation-associated
IHC: CD31, ERG, MYC
History of prostate cancer treated with external beam radiotherapy six years earlier.
Angiosarcoma, radiation-associated
IHC: ERG, MYC
History of prostate cancer treated with external beam radiotherapy eight years earlier.
IHC: MDM2, CDK4
FISH: MDM2 amplified
IHC: ERG
RNA-seq: WWTR1::CAMTA1Â gene fusion
RNA-seq: FN1::ALK gene fusion
Leiomyosarcoma, cyclophosphamide-associated
IHC: H-caldesmon
Lipoblastoma-like tumour, of scrootum
 Lobulated; spindle cells in loose fascicles
Pale eosinophilic cytoplasm
Ovoid euchromatic nuclei; inconspicuous mitotic activity
Collagenous stroma; delicate vasculature
Sheets of uni- and multivacuolated lipoblasts
IHC: S100, CD34
RNA-seq: Negative
Postoperative spindle cell nodule
Recent TURBT for low-grade papillary urothelial carcinoma
IHC: smooth muscle actin, keratin (AE1/AE3)
RNA-seq: negative
Radiation-associated sarcoma
Kidney
Angiomyolipoma
IHC: H-caldesmon, HMB45, Melan-A
IHC: ERG
RNA-seq: WWTR1::ACTL6AÂ gene fusion
This fusion gene has a predilection for tumours of cardiac origin
IHC: CD99
RNA-seq: EWSR1::FLI1 gene fusion
Perinephric myxoid pseudotumour
PMID: 30826321
Renomedullary interstitial tumour
RNA-seq: negative
PMID: 4264334, 27635944
Synovial sarcoma. poorly differentiated
RNA-seq: SS18::SSX2 gene fusion
Scrotum
Scrotal calcinosis
Spermatic cord
Leiomyosarcoma
IHC: desmin, smooth muscle actin, H-caldesmon
IHC: MDM2, CDK4
FISH: MDM2 amplified
FISH: MDM2 amplified
IHC: myogenin
FISH: MDM2 amplified
Paratesticular fibrous pseudotumour
IHC: desmin, myogenin
FISH: MDM2 non-amplified
RNA-seq: negative
Schwannoma
IHC: S100
PMID: