Pathology: calcified chondroid mesenchymal neoplasm

Calcified chondroid mesenchymal neoplasm

  • Lobulated; hypocellular

  • Spindle-epithelioid cells with pale amphophilic cytoplasm

  • Round-ovoid nuclei with vesicular chromatin, mild atypia, occasional binucleation

  • Chondromyxoid stroma with 'grungy' calcification and foreign-body giant cells

  • IHC: D2-40, ERG, S100

  • RNA-seq: FN1::FGFR2 gene fusion

  • PMID: 33727696

Calcified chondroid mesenchymal neoplasm

  • Lobulated; hypocellular; spindle-epithelioid cells with patternless distribution

  • Pale amphophilic cytoplasm with indistinct cell borders

  • Monomorphic ovoid nuclei; inconspicuous mitotic activity

  • Cartilaginous matrix with so-called "grungy" calcification; interspersed osteoclast-type giant cells

  • IHC: ERG, D2-40

  • RNA-seq: FN1::FGFR2 gene fusion

  • PMID: 33727696

Calcified chondroid mesenchymal neoplasm

  • Lobulated; hypocellular; spindle-epithelioid cells with patternless distribution

  • Pale amphophilic cytoplasm with indistinct cell borders

  • Monomorphic ovoid nuclei; inconspicuous mitotic activity

  • Cartilaginous matrix with so-called "grungy" calcification; interspersed osteoclast-type giant cells

  • RNA-seq: FN1::FGFR1 gene fusion

  • PMID: 33727696

Calcified chondroid mesenchymal neoplasm

  • Lobulated; hypocellular; spindle-epithelioid cells with patternless distribution

  • Pale amphophilic cytoplasm with indistinct cell borders

  • Monomorphic ovoid nuclei with occasional binucleation; inconspicuous mitotic activity

  • Cartilaginous matrix with so-called "grungy" calcification; interspersed osteoclast-type giant cells

  • IHC: D2-40