Multinodular; variable cellularity; epithelioid-spindle cells with patternless architecture
Abundant eosinophilic cytoplasm
Round-ovoid nuclei with macronucleoli ("virocyte-like"), occasional binucleation ("Reed-Sternberg-like") and moderate pleomorphism; rare mitotic activity
Areas of myxoid stroma; mixed inflammatory infiltrate, including neutrophils, eosinophils, histiocytes, lymphocytes and plasma cells
Scattered pseudolipoblasts
RNA-seq: TOM1L2::BRAF gene fusion
PMID: 28692601
Variable cellularity; epithelioid-spindle cells with patternless architecture
Abundant eosinophilic cytoplasm
Round-ovoid nuclei with macronucleoli ("virocyte-like") and moderate pleomorphism; rare mitotic activity
Areas of myxoid stroma; mixed inflammatory infiltrate, including neutrophils, histiocytes, lymphocytes and plasma cells
Scattered pseudolipoblasts