Osteo-chondroid neoplasm
Chondroid matrix: moderately cellular, with polygonal cells arranged in small clusters; eosinophilic cytoplasm; hyperchromatic nuclei, with mild pleomorphism and inconspicuous mitotic activity
Osteoid matrix: anastomosing trabeculae of predominantly woven bone; moderately cellular; epithelioid cells with hyperchomatic nuclei
FISH: MDM2 non-amplified
Osteo-chondroid neoplasm
Chondroid matrix: moderately cellular, with polygonal cells arranged in small clusters; eosinophilic cytoplasm; hyperchromatic nuclei, with mild pleomorphism and inconspicuous mitotic activity
Osteoid matrix: anastomosing trabeculae of predominantly woven bone
IHC: p53
FISH: MDM2 non-amplified
Lobulated; osteo-chondroid neoplasm
Chondroid matrix: moderately cellular, with polygonal cells arranged in small clusters; eosinophilic cytoplasm; hyperchromatic nuclei, with mild pleomorphism and inconspicuous mitotic activity; patchy enchondral-type ossification
Osteoid matrix: anastomosing trabeculae of predominantly woven bone; moderately cellular; small epithelioid cells with hyperchomatic nuclei
FISH: MDM2 non-amplified