Pathology: Kaposi sarcoma

Kaposi sarcoma

  • Spindle cell fascicles-whorls

  • Amphophilic cytoplasm with occasional hyaline globules

  • Monomorphic ovoid nuclei with small nucleoli; mitotic activity

  • Necrosis; mild chronic inflammatory infiltrate

  • IHC: CD31, HHV8 (x2)*

* NB: speckled pattern on higher magnification

Kaposi sarcoma

  • Spindle cell fascicles

  • Amphophilic cytoplasm with occasional hyaline globules

  • Monomorphic ovoid nuclei with small nucleoli; mitotic activity

  • Brisk lymphoplasmacytic inflammatory infiltrate; interstitial haemorrhage with abundant siderophages

  • IHC: HHV8

Kaposi sarcoma

  • Spindle cell fascicles

  • Amphophilic cytoplasm with occasional hyaline globules

  • Monomorphic ovoid nuclei with small nucleoli; mitotic activity

  • Mild lymphoplasmacytic inflammatory infiltrate; interstitial haemorrhage with occasional siderophages

  • IHC: HHV8

Kaposi sarcoma

  • Spindle cell fascicles-whorls

  • Eosinophilic-amphophilic cytoplasm with occasional clear vacuoles and hyaline globules

  • Monomorphic ovoid nuclei with small nucleoli; mitotic activity

  • Minimal chronic inflammation

  • IHC: ERG, HHV8

Kaposi sarcoma

  • Nests of epithelioid cells focally lining slit-like spaces

  • Amphophilic cytoplasm with occasional hyaline globules

  • Hyperchromatic round-ovoid nuclei with mild atypia and prominent small nucleoli; mitotic activity

  • "Crush" artifact; apoptotic debris; mild chronic inflammatory infiltrate

  • IHC: ERG, HHV8